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Clinically, AD manifests a relentless decline in memory, executive function, and cognitive function, ultimately compromising an individuals ability to perform daily activities

Fifty years of research on schizophrenia: the ascendance of the glutamatergic synapse
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L.WilsonD.HubeB

Geneva: WHO Food Additives Series

The first step, catalyzed by glutamate-cysteine ligase (GCL), is rate-limiting and regulated by GSH (competitive inhibitor) and by cysteine availability ( GSH degradation is catalized by -glutamyltranspeptidase (GGT), an enzyme that catalyzes the cleavage of the peptide bond between cysteine and the -carboxyl group of glutamate, and the transfer of the -glutamyl moiety to water (hydrolysis), an amino acid, or a short peptide (transpeptidation) (Figure 1)

doi: 10.1111/j.1432-1033.1997.00064.x
