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Handy DE, Loscalzo J (2022) The role of glutathione peroxidase-1 in health and disease

[DOI] [PubMed] [Google Scholar] 24.Werns SW, Fantone JC, Ventura A, Lucchesi BR

This action, combined with the induction of GLT1 in astrocytes, may at least in part account for the beneficial effects of NAC in conditions associated with excessive release of glutamate and impairment of glutamate homeostasis, and characterized by maladaptive synaptic plasticity and excitotoxic neuronal death [113]

Surprisingly, while these two molecules alone were able to inhibit the A aggregation in vitro , the combination wasnt effective

GSH serves as backup of thioredoxin in thiolredox maintenance So far, by highlighting its role in iron metabolism while minimizing its impact on thiolredox control, except for the high GSH levels on the ER, all data that were presented questioned the notion of the primary role of GSH in reducing oxidized Cys residues

Oxygen therapies used both in the delivery room and during hospitalization, immature organ development, and inflammatory/infective complications make the condition of preterm birth vulnerable to tissue injury 111,112