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Description
These effects are often studied through molecular markers rather than behavioral outcomes, reinforcing the strictly mechanistic nature of this research

Support ongoing evaluation and modification of the treatment plan for optimal effectiveness

doi: 10.1038/s41423-020-00630-3

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Common, mild effects: Temporary soreness or redness at the injection site
Microglia play a crucial role in orchestrating this phenotypic shift: upon activation, they release inflammatory mediators such as IL-1, TNF- and C1q, which induce a pro-inflammatory reactive astrocyte phenotype (often termed A1-like or neurotoxic reactive state) (Zhao et al., 2024
