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Collectively, the results of this study illustrate that AOD9604 exerts distinct metabolic effects depending on the genetic background of the animal and the presence of functional 3-ARs
Parallel research on NAD biology (e.g., precursors like NR/NMN) reinforces the centrality of NAD to mitochondrial output and recoverymechanistically aligned with 5-Amino-1MQs NNMT inhibition (Cant et al., Cell Metabolism )
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