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Finally, there are other neurotrophic factors that have shown dopaminergical neuronal protection in Parkinson-like models, including hepatocyte growth factor (HGF), mesencephalic astrocyte-derived neurotrophic factor (MANF), cerebral dopaminergic neurotrophic factor (CDNF), granulocyte colony-stimulating factor (G-CSF), and platelet derived growth factor (PDGF-CC) [31-32, 135-136]

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M., Mathur D., Susumu K., Oh E., Medintz I

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doi: 10.1038/s41580-019-0151-1 66 ChenX-YZhangJZhuJ-S

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Wang Q-W, Sun L-H, Zhang Y, Wang Z, Zhao Z, Wang Z-L, Wang K-Y, Li G-Z, Xu J-B, Ren C-Y, et al

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References 1 AlemkaA.NothaftH.ZhengJ.SzymanskiC

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Two ongoing phase I, randomized, double-blind, placebo-controlled trials are ongoing and aim to evaluate safety, tolerability and target engagement of DNL151 in healthy volunteers (NCT04557800) and PD patients (NCT04056689)

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