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Similarly, the genetic engineering of enzymes involved in VitB12 metabolism, for the study of deficiency, poses challenges, given that these enzymes appear to be engaged in other molecular activities beyond their enzymatic function or their use of VitB12 as a cofactor

Shellfish, fish, peanuts, tree nuts, soy, eggs and milk are frequent offenders

Ethics declarations Conflict of interest Author Yue Chen declares that he has no conflict of interest

For individuals experiencing mild gastrointestinal upset from B12 supplements (uncommon but possible with high doses), taking the supplement with breakfast may improve tolerance

doi: 10.1093/ije/dyv028

Strange CD, Truong MT , Ahuja J, Strange TA, Patel S, Marom EM