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A -Arr-biased agonist like carvedilol can expand on this therapeutic strategy through desensitization of the 1 -AR at the cell membrane via internalization as well as transactivation of EGFRs

Visualization and targeting of LGR5 human colon cancer stem cells
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The proposed mechanism includes modulation of oxidative stress and mitochondrial biogenesis

This refers to proteins downstream of the pathway altered by the signal