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461 These neurons also demonstrate increased spontaneous activity independent of ascending afferent input and possess enlarged receptive fields, suggesting that thalamic neurons function as central generators or amplifiers of pain in DPN

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[2] Closely related adamantanes with similar effects include adapromine, amantadine, chlodantane, gludantane (gludantan), memantine, and rimantadine

10.3389/fcvm.2022.833329 7 HeC

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