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Description

Alving's group (Chicago) performed experiments in human volunteers in order to detail the clinical and haematological features (see Fig 1) of the acute haemolytic anaemia (AHA) triggered by PQ (Tarlov et al , 1962) (the volunteers were inmates of a penitentiary near Chicago who were clinically and haematologically normal at the start of the experiment, but suffered AHA as a result of the experiment

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Broadly, these data show the importance of dopamine in the regulation of immune function and the need for further studies with carefully considered experimental designs to better understand and leverage dopaminergic immunomodulation for disease treatment