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Using the maleimide chemistries outlined above produces conjugation heterogeneity and destabilizes the higher order structure of the IgG due to the loss of these interchain cross-linkages (24)

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Targeting mitochondrial oxidative stress and dysfunction Currently, clinical treatment of AIH mainly focuses on mitochondrial oxidative stress

The AMBER19SB force field 55 was applied to the tyrosinase complexes 56,57,58