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GlyT1 (SLC6A9) inhibition in neurological and psychiatric disorders

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As gut microbiota translocates to the aortic artery due to defect in gut barrier integrity, microbial-derived metabolites and inflammation results in renal insufficiency and inflammation-signaling pathway

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designed an RVG29-modified nanomedicine (RVG-nDMC) to deliver 4,4-dimethoxychalcone (DMC) to immune cells and dopaminergic neurons in the brain in order to relieve neuroinflammation and oxidative stress in dopaminergic neurons (Fig