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Hypoxia sustains glioblastoma radioresistance through ERKs/DNA-PKcs/HIF-1 functional interplay

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Whole-genome sequencing (WGS) represents the current gold standard, simultaneously providing data on identification, antimicrobial resistance, virulence factors, and clonal typing, although it requires high investment, specialized infrastructure, and bioinformatic processing (De Maio et al

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doi: 10.1016/j.autrev.2014.01.013 15 BartalenaLFatourechiV

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aeruginosa and other bacterial pathogens are present in nearly all CF patients, with widespread biofilm formation (99)

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Well tolerated in IV form

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Limited drug bioavailability due to low vascularization is also a feature of hypoxic tumor cells (166)

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