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For instance, a previous study demonstrated that dexmedetomidine, an 2-adrenergic receptor agonist, reduced oxidative stress and airway inflammation in a murine asthma model by activating the Nrf2 pathway, which increases the expression of antioxidant genes such as heme oxygenase 1 (HO-1) and glutathione peroxidase 4 [104]

doi: 10.1016/j.jtemb.2024.127385

Evidence neutrophils contribute to cuprizone demyelination Neutrophils are innate immune cells that responds to inflammatory stimuli to sense and kill pathogens [265]

Skin is the external barrier and prevents entry of germs, chemicals and UV

doi: 10.1186/s13023-022-02453-z