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Some forms of damage to biochemical structures occur from the reaction of chemically reactive (usually) small molecules with the nucleophilic centers of proteins and of DNA, that generate stable addition products, commonly referred to as adducts [83]

In practice, KDs may serve as a useful adjunct in select populations, such as individuals with Hashimotos thyroiditis seeking autoimmune and metabolic stabilization, patients with obesity-related TSH elevation, or those with insulin resistance where improved leptin and glucose regulation may indirectly benefit thyroid function

[] Mumtaz et al

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doi: 10.1212/WNL.0b013e31824d586c

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