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Description
GLP-1 acts on the GLP-1R, activating multiple intracellular signaling pathways, including the cAMP/PKA pathway, the PI3K/Akt signaling pathway, and pathways related to anti-inflammatory and anti-oxidative stress responses, among others
doi: 10.1038/187067a0
Accumulation of sorbitol results in elevated levels of reactive oxygen species, increased cellular damage and osmotic stress leading to diabetic complications [130]
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Lyophilized AOD-9604 should be stored at -20C in a dry, light-protected environment prior to use
Once-weekly injectable : Convenient, easy-to-use subcutaneous injection with a pre-filled pen
