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B-complex (B1, B2, B3, B5, B6): Essential for energy metabolism, nervous system function, and stress response

OTA has also been reported as nephrotoxic, hepatotoxic, embryotoxic, teratogenic, neurotoxic, immunotoxic, and genotoxic ( The human aspects of OTA poisoning are not yet fully understood, although OTA in humans can cause kidney damage, cancer, or kidney failure, according to previous studies (Figure 4

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One aspect of this study that may be missed are the overall excellent responses achieved with only a moderate dose of methotrexate, highlighting the potency of methotrexate as a DMARD which can often be overlooked in clinical trials that typically enroll only subjects with inadequate responses to methotrexate