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It can be given via IV or injection

Folylpoly--glutamate synthetase: A key determinant of folate homeostasis and antifolate resistance in cancer

doi: 10.1103/PhysRevLett.121.118103

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While most studies included a non-differentiated ASD sample, Wink et al
Statistical significance was evaluated using the log-rank test and Cox proportional regression analysis to calculate the hazard ratios
