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Carnitine deficiency occurs in VPA use, and is thought to be ultimately responsible for increased ammonia production

Prolonged L-carnitine supplementation was associated with normalization in plasma ammonia concentrations and marked increase in carnitine concentration in all 15 patients

Acetyl-L-carnitine supplementation to old rats partially reverts the age-related mitochondrial decay of soleus muscle by activating peroxisome proliferator-activated receptor gamma coactivator-1alpha-dependent mitochondrial biogenesis

Finally, -butyrobetaine hydroxylase catalyzes the hydroxylation of - N -trimethylaminobutyrate to generate L-carnitine, requiring Fe 2+ and ascorbate

Qinfeng Zhang: Writing review & editing, Funding

For each assay, 2 mL of DPPH solution was mixed with 2 mL of test sample and incubated in the dark at room temperature for 30 min