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Below is a snap-shot of my DCF model

In the acute window (024 h) the priority is to contain ROS spikes (e.g., ischemiareperfusion, SIRS) by attenuating the source (NOX/mitochondrial bursts), buffering at the compartment of origin (mitochondria, ER, endothelium) and controlling free metals that license Fenton chemistry

Notably, the adverse effects caused by metformin therapy for adolescent patients with PCOS, especially gastrointestinal side effects, need to be a concern, as they may affect their quality of life and treatment adherence

doi: 10.1139/o05-036

Tang, R.-H

In 1984, the successful isolation and culture of human dermal papilla cells (hDPCs) in vitro addressed the challenge of obtaining sufficient human tissue [22]