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Oxidative stress reduces the longevity of the ovary by direct cell loss and chronic inflammation

Trenkwalder, C

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Although epidemiologic studies have shown an association between vascular disease and hyperhomocysteinemia, large randomized controlled trials have shown that lowering homocysteine levels in these patients does not reduce the number of myocardial infarctions or strokes, or improve mortality rates

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Patients show symptoms well above this mark, as B12 depletion appears in the cerebrospinal fluid even when blood levels are as high as 550