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R-cells, involved in nutrient uptake, metabolism, mineral excretion, and lipid storage (Vogt, 2019), its count related to the healthier hepatopancreas and facilitated hepatopancreas energy reserves (Pourmozaffar et al., 2019

Among them, the glutamate produced by the decomposition of glutamine via GLS not only provides the raw material for the synthesis of GSH but is also further metabolized into -ketoglutarate (-KG) in the mitochondria under the action of glutamate dehydrogenase (GLUD1) or transaminases and then enters the tricarboxylic acid cycle to produce ATP [29]

World J Gastroenterol 28:5910

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Mechanistically, RanBPM protein physically interacts with p21, and RanBPM deubiquitinates p21 by recruiting a deubiquitinase USP11 to maintain protein stability of p21

Oxidative glutamate toxicity can be a component of the excitotoxicity cascade