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( Radioligand access to brain is modified by general metabolism, which can differ across cases and controls One common theory of ME/CFS is that it is, at root, a disorder of mitochondrial dysfunction and reduced metabolism [e.g., ( Activated peripheral immune cells bind radioligand and can differ in quantity across cases and controls While PBR28 has improved non-specific binding, the antigen that it binds to can occur in non-target tissues and in blood