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This review describes the structural diversity of these pro-moieties, relevant cleavage mechanisms and recent advances in the design of phosphonate prodrugs

Hum Reprod (2002) 17(12):31629

This signal intensity increased for 1 week after which it gradually turned into green due to removal of the NPs

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However, its C-terminal end can be cleaved by carboxypeptidase A, and removal of the last leucine residue (L585) weakens receptor binding, reducing its half-life from 20 days to 3.5 days in humans