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For instance, in the cardiomyocytes and fibroblasts of rats treated with ISO, the expressions of basic fibroblast growth factor 2 (FGF2), collagen I and smooth muscle -actin (-SMA) significantly increased and promoted CF (247)

The effects can range from small cellular changes to the death of individuals and might include behavioral and reproductive disorders

Ilkayeva, R.D

Heuer, L

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However, it should be mentioned that Laron subjects are not longer lived than normal subjects eating a Western diet and if not properly treated die of cardiovascular diseases