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Inhibitory effect of astragalus polysaccharide on premetastatic niche of lung cancer through the S1PR1-STAT3 signaling pathway

When internalized by NSCs, MNBs activate Piezo1 channels, leading to Ca 2+ influx, which activates the expression of BMP2 and increases the phosphorylation of SMAD, adjusting the expression of differentiation genes to prevent NSCs from expressing genes that promote cancer (Li J

While cuproptosis and ferroptosis are currently understood to operate through distinct mechanisms, future research may uncover synergistic effects between them

( 10.1073/pnas.0902714106) [DOI] [PMC free article] [PubMed] [Google Scholar] 139.Fleming JL, Phiel CJ, Toland AE

doi: 10.1093/bib/bbae350

(ii) Developing orthotopic tumor-bearing animal models is particularly challenging due to the technical complexity of tumor transplantation surgery, the need for intensive post-operative care, the highly heterogeneous tumor microenvironment (TME) of pancreatic cancer, and the inherent variability in tumor growth and experimental timelines (Stribbling et al., 2024)