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In our tinnitus model, we did not observe an increased expression of TNF- in the auditory cortex of WT mice with tinnitus-like behavior

Therapeutic strategies targeting redox-critical nodes include caspase/RIPK1 inhibition, GPX4 activators, autophagy modulators (rapamycin), acid -glucocerebrosidase (GBA1) restoration, iron/copper chelators, and antioxidants (N-acetylcysteine) to restore glutathione homeostasis

Furthermore, IRE1 can directly activate caspase-12, leading to cell death in a rat model of virus-induced diabetes (78)

PMID: 36 WuVSKanayaNLoCMortimerJChenS

Mittal M, Siddiqui MR, Tran K, Reddy SP, Malik AB (2014) Reactive oxygen species in inflammation and tissue injury

Bellver-Landete, V