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These enzymes form a multienzyme metabolic complex, which translocates to the nucleus during S (DNA replication) and G2/M (DNA damage checkpoint) phases, and is required for biosynthesis of the nucleotide precursor, thymidylate, which is critical to DNA synthesis and repair

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Endogenous Compounds There are many types of adducts formed between GSH and divergent endogenous compounds, all of which have key functions (Table 3)