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As a single case report, it is constrained by a limited sample size and lacks systematic biomarker profiling

Feb 6 2024;83(5):549-558

Understanding the science, limitations, and safety considerations is essential before considering supplementation

For example, excess dietary and biliary cholesterol leads to the downregulation of the LDLR and HMG-CoA reductase and an increase in LDL-C

Analysis of 14 paired liver biopsies revealed significantly lower baseline peripheral mtDNA copy number in NASH versus simple steatosis patients, establishing an association between mitochondrial dysfunction and disease severity