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After 24 weeks of thiamidol 0.2% applied twice daily, 23 women with facial melasma experienced a mean MASI reduction of 26%

Lidocaine cream was applied to one side of the face, while infraorbital and zygomaticofacial nerve blocks were applied to the other

doi: 10.1093/nar/gkaa1154 [DOI] [PMC free article] [PubMed] [Google Scholar] 21

Promotion of Pheomelanin Production: Glutathione may promote the production of pheomelanin, a lighter form of melanin, rather than eumelanin, which is associated with darker skin tones

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Front Pharmacol 12:782660 Li P, Inoue Y, Miyamoto D, Adachi T, Okada S, Adachi T, Soyama A, Hidaka M, Kanetaka K, Ito S (2023) Therapeutic effect and mechanism of Daikenchuto in a model of methotrexate-induced acute small intestinal mucositis