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Concretely, GPX4 uses GSH as the substrate to reduce phospholipid hydroperoxides (PLOOHs) to hydroxyl derivatives (PLOHs), and oxidizes GSH to GSSH, therefore alleviating the damage of oxidative stress to tumor cells ( As a case in point, Li and co-workers loaded dihydroartemisinin (DHA) into iron-based MOFs to design a peroxidase-like nanoreactor (termed DHA@MIL-101 NR) for synergistic CDT-ferroptotic therapy (Figure 5C) ( 3+ , achieving GSH consumption-mediated redox reaction and Fe 2+ -mediated Fenton reaction (Figure 5D)

Importantly, the gpoA , ahpD , and tpxD mutants showed a similar H 2 O 2 susceptibility, representing a 12-fold decrease compared to the wild-type ( wt ) strain (Fig 3B, Fig S2)

10.1006/abbi.1994.1014 Arch

In 2012, Huang et al (85) demonstrated that antiangiogenic treatment influences the effectiveness of immunotherapy by the modulatory activity of antiangiogenic agents on tumor microenvironment

Additionally, our IV Drip Therapy aids digestion, boosts metabolism, and provides immune system support

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