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The PEN form does not change any of these mechanisms

3.2 Mitochondrial DNA mutations Mitochondrial DNA (mtDNA) is particularly vulnerable to injury in the failing heart (Nakayama and Otsu, 2018)
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Garlic contains more than 33 different organic sulfur compounds, which are responsible for its specific flavor and pharmacological effects (De Greef et al., 2020)

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Both MPSS and minocycline are considered immunosuppressive strategies, traditionally showing some clinical benefits and applications