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[109] [118] Moreover, animal studies and at least three human case reports have found no interaction between ketamine and the monoamine oxidase inhibitor (MAOI) tranylcypromine, which is of importance as the combination of a monoamine reuptake inhibitor with an MAOI can produce severe toxicity such as serotonin syndrome or hypertensive crisis

Stopping the use of these substances abruptly leads to withdrawal symptoms, as the brain struggles to balance GABA levels without external help

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