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it has systemic repercussions, leading to endotoxemia (Canton et al., 2021

Gao XQ, Liu CZ, Li DD, Zhao TT, Li F, Jia XN, et al

An ongoing, prospective clinical registry capturing outcomes in patients with full-thickness wounds and ulcerations, with a preference for undermining/tunneling or cavity defects that are commonly excluded from randomized trials

Montesinos MC, Desai D et al (2003): Adenosine A2A or A3 receptors are required for inhibition of inflammation by methotrexate and its analog MX-68

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The AhR resides in the cytoplasm and, upon ligand binding, moves to the nucleus, where it heterodimerizes with the AhR nuclear translocator
