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Ethosomal gels and cataplasms represent semi-solid formulations that enhance topical drug delivery through matrix-controlled release kinetics and prolonged skin retention

doi: 10.3389/fgene.2014.00112 90 HanJKaufmanRJ

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Key challenges including volatility, poor aqueous solubility, and metabolic instability necessitate the use of advanced formulation strategies such as nanoemulsions, lipid-based nanoparticles, targeted delivery systems, and polymeric films to enhance their antibacterial efficacy and stability (Figure 8)

Tetrahedron Lett 2004

The deposition of the powder and absorption of the drug from a powder formulation for nasal delivery depends on many factors, including the shape and size of powder particles, solubility, and flow characteristics [18]