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It is a membrane stabilizer and counteracts gut-leaky syndromehas profound cytoprotective activityand specifically [controls] the VEGF [vascular endothelial growth factor] and NO [nitric oxide] pathways, in particular the prostaglandin pathway (Sikiric et al, 2022)

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Vitamin B6 (Pyridoxine) acts as a necessary cofactor in the folate cycle and combines with serine hydroxymethyl transferase to effect the conversion of tetrahydrofolate(THF) to 5,10 methylene THF (14)