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The safety profile of AXA1125, combined with its potential to improve mitochondrial function and reduce oxidative damage, warrants further investigation in clinical trials in ME/CFS and GWS patients

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However they also show differences in the overall fold with the presence of a DsbA-like domain inserted within the N-terminal thioredoxin-like domain 6

This is probably due to the differing levels of susceptibility of different brain regions to OS

The authors hypothesize that the acidification hypersensitizes the transient receptor potential (TRP)A1 channel but could also be explained by the participation of TRPM8 and TRPV1 channels, which have been implicated in this side effect (Riva et al., 2018)

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