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Research Mechanism (Mechanism of Action) NNMT normally catalyses the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing 1-methylnicotinamide (1-MNA)

Benefits: Helps convert food into energy

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Daily NNMT inhibitor effects on body weight measures in DIO mice was analyzed using a repeated measures two-way ANOVA with Sidaks multiple comparison posthoc test

Methionine is needed for DNA synthesis and methylation reactions

Non-negotiable targets: Protein: 80-100g daily minimum (prevents muscle loss during weight loss) Calories: Dont go below 1,200 (women) or 1,500 (men) despite suppressed appetite Fiber: 25-35g daily (prevents constipation, supports gut health) Healthy fats: 30-50g daily (prevents gallbladder issues during rapid weight loss) Meal structure moving forward: Still smaller frequent meals (5-6 per day)