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Nisamedtinov I, Kevvai K, Orumets K, Arike L, Sarand I, Korhola M, et al
8% at 240 Units total dose) compared to placebo (6%)

Expert Opinion on Drug Deliv

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Benefits of B12 Injections: Might Reduce Depression, Cognitive Decline and Dementia: Some studies show that, especially in older people, supplementing with vitamin B12 can prevent depression, restore better mood control and retain healthy memory/mental functioning

Human trial data is limited to a handful of small pilot studies, and a 2025 University of Utah review concludes BPC-157 should be considered investigational
