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Symptoms include intense burning or stinging at the site, skin that shifts from pale to red to blistered, and in severe cases, tissue death

Psychiatry Res 186, 427430 (2011)

FDA-approved peptides like GLP-1 medications have a risk of side effects like nausea, vomiting, constipation, and diarrhea

J Neurosci Res 98:24682495

Their concerns are not small ones

By leveraging the olfactory epithelium and its associated neural pathways, this method capitalizes on the large surface area, efficient blood flow, and neural connections of the nasal mucosa to provide a relatively non-invasive approach towards efficient peptide delivery into the brain [41-46]