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Future research should prioritize the development of receptor-selective modulators with proven long-term efficacy, capitalizing on astrocyte-specific biology to optimize neuroprotective therapeutic outcomes

doi: 10.1371/journal.pmed.0030091

PMCID: PMC7791774

However, considerable preclinical and clinical evidence now points to significant neuralimmune interactions and a bidirectional communication between the nervous and immune systems

There is no strong clinical evidence that vitamin B12 injections provide meaningful health benefits to individuals who are not deficient

Its potential is in a real biological effect involving tissue repair, control of inflammation, development of blood vessels, as well as in a general positive safety profile observed in animal studies and off-label use