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Description
The larger the defect the more likely it is to recur after repair with only sutures

Martin GS, et al

doi: 10.1186/s13287-016-0287-2 229 DuanYRChenBPChenFYangSXZhuCYMaYLet al

The takeaway is straightforward

Science 357:10471052

As NAD+ declines, skin becomes thinner, drier, and more prone to wrinkles and damage