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\n\n\n\n It is critical to note, however, that preclinical safety data no matter how consistently positive cannot be directly extrapolated to humans without proper clinical trials

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95 AMPs, predominantly secreted by Paneth cells, are vital for gut homeostasis by controlling pathogenic and commensal bacterial populations

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Given the possibility that cimetidine may benefit a subset of patients without significant AEs in the context of a small total sample exposed to the drug (n=40, including the RCT), the lack of long-term follow-up data on sufficient numbers of patients, and its potential to interact with other drugs, oral cimetidine was designated as an Option