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In large human studies, elevated TMAO levels have been independently associated with atherosclerotic heart disease and have been shown to predict major adverse cardiac events [68]

Trimethylamine-N-Oxide Pathway: A Potential Target for the Treatment of MAFLD

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[17] Localized adverse reactions-transient erythema, warmth, pruritus, or mild burning-occur in up to one-third of users and are generally self-limiting

Two copies of FMO3 mutations are generally needed to cause trimethylaminuria

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