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10.1016/j.cyto.2016.06.015 Cytokine 117 PandeyV.PerryJ

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For instance, 34% of patients being considered for lumiracoxib would be excluded if they carry the HLA-DQA1*0102 allele, yet only 5.6% of these individuals are expected to develop DILI

Finally, in hippocampal neurons overexpressing a Mfn2 mutant, Mfn2 R94Q, with impaired fusion and transport properties, it was confirmed that a dysregulation of mitochondrial fission/fusion events greatly contributed to the reported trafficking phenotype