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Further rigorously designed RCTs are required to conclusively establish both efficacy and safety

Additionally, itaconate can activate NOCAD 4-mediated ferritin deposition, thereby inducing ferroptosis in Nrf2-deficient cell lines [119]

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MatsuzawaDObataTShirayamaYNonakaHKanazawaYYoshitomeEet alNegative correlation between brain glutathione level and negative symptoms in schizophrenia: a 3T 1H-MRS study

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Serum ferritin, a complex of Fe ions and Apoferritin, is responsible for storing and buffering excess Fe, and is the most sensitive indicator of ID, therefore, it has a good diagnostic and predictive value for ID ( 3.1 Iron and hypothyroidism 3.1.1 Iron deficiency and hypothyroidism 3.1.1.1 Clinical study on the relationship between iron and hypothyroidism ID exerts a significant impact on thyroid function