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Annu Rev Pharmacol Toxicol 45:5188 Kato R, Yamazoe Y (1994) Metabolic activation of N-hydroxylated metabolites of carcinogenic and mutagenic arylamines and arylamides by esterification

3.2.1 Designing tRNA based on structure information The fundamental approach to rational design involves analyzing the sequence and structure of tRNA, as well as the structure of tRNA binding sites in proteins that interact with it

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45 Such cyto-architecture however, may not be common for all species

This is primarily because these compounds have three major drawbacks limiting their use in clinical settings

In particular, several such clinical trials have been terminated prematurely due to accelerated cancer progression and higher incidence of cancer-related mortality 45,47,48