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Keywords: Nitric oxide, Hydrogen sulfide, COVID-19, Inflammation, Endothelium, iNOS, Cytokine storm, Antiviral Graphical abstract Abbreviations 3-MST 3-mercaptopyruvate sulfurtransferase ACE2 angiotensin converting enzyme 2 ALI acute lung injury Ang angiotensin ARDS acute respiratory distress syndrome Atf3 activating transcription factor 3 Ca 2+ calcium ion CAT cysteine aminotransferase CBS cystathionine -synthase CCHFV Crimean-Congo hemorrhagic fever virus CF cystic fibrosis cGMP cyclic guanosine monophosphate CMV cytomegalovirus COPD chronic obstructive pulmonary disease COVID-19 coronavirus disease 2019 CRP C-reactive protein CSE cystathionine -lyase EBOV recombinant Zaire Ebola virus ECMO extracorporeal membrane oxygenation ED emergency department eNOS endothelial nitric oxide synthase GADD45 growth arrest and DNA-damage-inducible 45 alpha GSH glutathione H 2 S hydrogen sulfide

Any disagreements between the first two reviewers regarding extracted data were resolved through discussion by a third reviewer

After a 6h fasting period, the control group was administered purified water orally, whereas the treatment group received Ltheanine via oral gavage

For individuals managing metabolic health or pursuing precision wellness strategies, understanding your baseline antioxidant capacity and genetic predispositions to oxidative stress can clarify whether liposomal glutathione fits your personalized health framework

Altered pharmacokinetics ( discussed further in the section below ): Extended-release acetaminophen preparations