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pHLIPs spontaneously fold to form helices, which insert and cross the cell membrane to transport conjugated NADs into cells

Percentages of cross-sectional areas showing metastatic tumours were calculated by Image-J as previously described 7

[DOI] [Google Scholar] 3.Zhou Z., Curtis A.J., Breslin M., Nelson M

Psychiatry 70, 148161

A study in adults aged 70 and older showed increased heteroplasmy linked to an increased depression score.[ref] Rare mitochondrial mutations that cause mitochondrial diseases are also linked to major depressive disorder.[ref] In fact, one study of people with hereditary (genetic) mitochondrial diseases showed that 54% had major depressive disorder and 17% had bipolar disorder.[ref] Outside of the mitochondrial genome, genes in the nuclear genome that code for proteins in the mitochondria are also linked to depression