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Given the profound protection against oxalate-induced progressive renal insufficiency in mice deficient for NLRP3, future studies should examine these compounds in the established murine models of oxalate-induced CKD and crystal-induced progressive renal failure [81, 108]

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Similar content being viewed by others Introduction Nicotinamide adenine dinucleotide phosphate (NADP), in its reduced (NADPH) and oxidised (NADP + ) states, constitutes a central metabolic redox couple, which is found in all living organisms