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These differences highlight the interplay between genetic background and environmental exposure

Concentrations and dosing vary depending on experimental design, but common in vitro concentrations range from micromolar to low millimolar levels

& Aldakhil, T

For example, GRACILE syndrome ( G rowth R etardation, A mino aciduria, C holestasis, I ron overload, L actic acidosis, and E arly death) is caused by mutations in the BCS1L gene which is required for proper assembly of complex III

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Fiumara P, Snell V, Li Y, Mukhopadhyay A, Younes M, Andreeff M , Cabanillas F, Carbone A, Aggarwal B, Younes A